Grenades are a handy tool to have when you need to clear out a room full of enemies, destroying parked vehicles or causing general mayhem. To prime a grenade hold down the R2 button, then release to throw. Remeber, you have roughly 4-5 seconds to throw the grenade when primed or else it goes off in Niko’s hand…
Here are several ways of using the grenade:
#1 Lock-on Throw: Hold the L2 button to target an enemy to throw the grenade at. Press/hold R2 to throw.
#2 The Free Look Throw: Exactly like free-look aim, hold the L2 button down lightly and aim the throw using the right analog stick.
#3 Blind-Fire Throw: While behind any type of cover, hold the L2 button lightly to use free-look mode, aim where you want the grenade to go, then throw the grenade. Niko will automatically throw the grenade over, and around whatever object you are using as cover.
And yes, you can toss grenades into open car windows…