There are 3 types of weapons that you can use while operating a vehicle. The pistol, a sub machine gun and the Molotov/grenade can all be selected while driving in GTA IV. To fire a gun inside a car simply hold R1 and aim the firing reticule using the right analog.

Cars with their windows up will cause Niko to first smash them out with his fist if you press L1. A good habit to get into is breaking out the glass beforehand if you know that you are going to use a gun or grenade soon.

To change weapons while in a vehicle, press square. You do not need to reload a weapon while in a car, it is done automatically for you.

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